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International Journal of Biological Sciences Volume 4


Post-Weaning Protein Malnutrition in the Rat Produces Short and Long Term Metabolic Impairment, in Contrast to Earlier and Later Periods
María del Carmen Miñana-Solis, Carolina Escobar More detail

Indexed in Medline/PubMed. Full text is beautifully presented and linked. High exposure on the Internet and search engines. Authors can also publish a biography together with the paper.
Biolsci.org
Malnutrition during gestation and lactation modifies metabolic strategies and leads to metabolic disease in adult life. Studies in human populations suggest that malnutrition during infancy may also induce long term metabolic disorders. The present study investigated if post-weaning and a late period of development might be sensitive for long term ...

cDNA, genomic sequence and overexpression of crystallin alpha-B Gene (CRYAB) of the Giant Panda
Yi-ling Hou, Wan-ru Hou, Zheng-long Ren, Yan-zhe Hao, Tian Zhang More detail

αB-crystallin, a small heat-shock protein, has been shown to prevent the aggregation of other proteins under various stress conditions. Here we have cloned the cDNA and the genomic sequence of CRYAB gene from the Giant Panda (Ailuropoda melanoleuca) using RT-PCR technology and Touchdown-PCR, respectively. The length of cDNA fragment cloned ...

Genome Assembly Anchored QTL Map of Bovine Chromosome 14
Tito A. Wibowo, Charles T. Gaskins, Ruth C. Newberry, Gary H. Thorgaard, Jennifer J. Michal, Zhihua Jiang More detail

Bovine chromosome 14 (BTA14) has been widely explored for quantitative trait loci (QTL) and genes related to economically important traits in both dairy and beef cattle. We reviewed more than 40 investigations and anchored 126 QTL to the current genome assembly (Btau 4_0). Using this anchored QTL map, we observed that, in dairy cattle, the region ...

Comparing methods of detection and quantitation of RNA editing of rat glycine receptor alpha3P185L
Aya Nakae, Tatsuya Tanaka, Keiko Miyake, Makiko Hase, Takashi Mashimo More detail

Background: Recently, it has become evident that RNA editing-related changes are important in the modulation of neuronal information processing. Alternatively edited transcripts, when meagerly present, are hard to detect. Significant functional consequences may result, however, from small differences in editing efficiency. Moreover, it is ...

LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11
Koji Sagane, Yasushi Ishihama, Hachiro Sugimoto More detail

The transmembrane protein ADAM22 is expressed at high levels in the brain. From its molecular structure, ADAM22 is thought to be an adhesion molecule or a receptor because it has functional disintegrin-like and cysteine-rich sequences in its ectodomain. The phenotypic analysis of ADAM22-deficient mice has indicated the important roles played by ...

Production & Characterization of a Unique Dextran from an Indigenous Leuconostoc mesenteroides CMG713
Farwa Sarwat, Shah Ali Ul Qader, Afsheen Aman, Nuzhat Ahmed More detail

On the basis of high enzyme activity a newly isolated strain of L. mesenteroides CMG713 was selected for dextran production. For maximum yield of dextran, effects of various parameters such as pH, temperature, sucrose concentration and incubation period were studied. L. mesenteroides CMG713 produced maximum dextran after 20 hours of incubation at ...

Biological and functional analysis of statistically significant pathways deregulated in colon cancer by using gene expression profiles
Angela Distaso, Luca Abatangelo, Rosalia Maglietta, Teresa Maria Creanza, Ada Piepoli, Massimo Carella, Annarita D'Addabbo, Nicola Ancona More detail

Gene expression profiling offers a great opportunity for studying multi-factor diseases and for understanding the key role of genes in mechanisms which drive a normal cell to a cancer state. Single gene analysis is insufficient to describe the complex perturbations responsible for cancer onset, progression and invasion. A deeper understanding of ...

Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects
R. Vasudevan, Patimah Ismail, Johnson Stanslas, Norashikin Shamsudin, Aisyah binti Ali More detail

An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B gene in Malaysian essential hypertensive subjects ...

A PP1-binding motif present in BRCA1 plays a role in its DNA repair function
Young-Mi Yu, Serena M. Pace, Susan R. Allen, Chu-Xia Deng, Lih-Ching Hsu More detail

Protein phosphatase 1α (PP1α) regulates phosphorylation of BRCA1, which contains a PP1-binding motif 898KVTF901. Mutation of this motif greatly reduces the interaction between BRCA1 and PP1α. Here we show that mutation of the PP1-binding motif abolishes the ability of BRCA1 to enhance survival of Brca1-deficient mouse mammary tumor ...

Significant associations of stearoyl-CoA desaturase (SCD1) gene with fat deposition and composition in skeletal muscle
Zhihua Jiang, Jennifer J. Michal, David J. Tobey, Tyler F. Daniels, Daniel C. Rule, Michael D. MacNeil More detail

Gene expression studies in humans and animals have shown that elevated stearoyl-CoA desaturase (SCD1) activity is associated with increased fat accumulation and monounsaturation of saturated fatty acids in skeletal muscle. However, results of the two reported association studies in humans are inconsistent. In the present study, we annotated the ...

Inducible SOS Response System of DNA Repair and Mutagenesis in Escherichia coli
Celina Janion More detail

Chromosomal DNA is exposed to continuous damage and repair. Cells contain a number of proteins and specific DNA repair systems that help maintain its correct structure. The SOS response was the first DNA repair system described in Escherichia coli induced upon treatment of bacteria with DNA damaging agents arrest DNA replication and cell division. ...

Antifungal Potential of Extracellular Metabolites Produced by Streptomyces hygroscopicus against Phytopathogenic Fungi
Benjaphorn Prapagdee, Chutima Kuekulvong, Skorn Mongkolsuk More detail

Leading positions on the Internet, cited by many prestigious sites, high exposure. Abstract indexed in Medline and PubMed, and full text in PubMed Central.
Biolsci.org
Indigenous actinomycetes isolated from rhizosphere soils were assessed for in vitro antagonism against Colletotrichum gloeosporioides and Sclerotium rolfsii. A potent antagonist against both plant pathogenic fungi, designated SRA14, was selected and identified as Streptomyces hygroscopicus. The strain SRA14 highly produced extracellular chitinase ...

Unveiling the Bmp13 Enigma: Redundant Morphogen or Crucial Regulator?
Lisa A Williams, Divya Bhargav, Ashish D Diwan More detail

Bone morphogenetic proteins are a diverse group of morphogens with influences not only on bone tissue, as the nomenclature suggests, but on multiple tissues in the body and often at crucial and influential periods in development. The purpose of this review is to identify and discuss current knowledge of one vertebrate BMP, Bone Morphogenetic ...

A combined computational-experimental analyses of selected metabolic enzymes in Pseudomonas species
Deepak Perumal, Chu Sing Lim, Vincent T.K. Chow, Kishore R. Sakharkar, Meena K. Sakharkar More detail

Comparative genomic analysis has revolutionized our ability to predict the metabolic subsystems that occur in newly sequenced genomes, and to explore the functional roles of the set of genes within each subsystem. These computational predictions can considerably reduce the volume of experimental studies required to assess basic metabolic ...

Effect of exercise training on calpain systems in lean and obese Zucker rats
Yao-Yuan Hsieh, Chi-Chen Chang, Kung-Hao Hsu, Fuu-Jen Tsai, Chih-Ping Chen, Horng-Der Tsai More detail

Exercise training plays a major role in the improving physiology of diabetes. Herein we aimed to investigate the influence of exercise upon the calcium-dependent calpain-isoform expressions of lean or obese Zucker rats, a model of obesity and type II diabetes (NIDDM). Five-month-old rats were divided: (1) obese sedentary (OS, n=7); (2) obese ...

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression
Kristi Muldoon Jacobs, J. Daniel Pennington, Kheem S. Bisht, Nukhet Aykin-Burns, Hyun-Seok Kim, Mark Mishra, Lunching Sun, Phuongmai Nguyen, Bong-Hyun Ahn, Jaime Leclerc, Chu-Xia Deng, Douglas R. Spitz, David Gius More detail

Cellular longevity is a complex process relevant to age-related diseases including but not limited to chronic illness such as diabetes and metabolic syndromes. Two gene families have been shown to play a role in the genetic regulation of longevity; the Sirtuin and FOXO families. It is also established that nuclear Sirtuins interact with and under ...

Advances in Susceptibility Genetics of Intervertebral Degenerative Disc Disease
Yin'gang Zhang, Zhengming Sun, Jiangtao Liu, Xiong Guo More detail

The traditional view that the etiology of lumbar disc herniation is primarily due to age, gender, occupation, smoking and exposure to vehicular vibration dominated much of the last century. Recent research indicates that heredity may be largely responsible for the degeneration as well as herniation of intervertebral discs. Since 1998, genetic ...

Discovery of four natural clones in a crayfish species Procambarus clarkii
G. H. Yue, G. L. Wang, B. Q. Zhu, C. M. Wang, Z .Y. Zhu, L. C. Lo More detail

Self-cloning is quite rare in shrimp, lobsters, crayfish and crabs. Here we report the discovery of four natural clones of red swamp crayfish (Procambarus clarkii), each containing 2-6 genetically identical individuals, during the genotyping of 120 individuals with five microsatellites. The four clones were heterozygote at most of the five ...

Preconditioning of Carbon Monoxide Releasing Molecule-derived CO Attenuates LPS-induced Activation of HUVEC
Bingwei Sun, Xiangqian Zou, Yueling Chen, Ping Zhang, Gengsheng Shi More detail

Objective: To investigate the effects and potential mechanisms of preconditioning of tricarbonyldichlororuthenium (III) dimer (CORM-2)-liberated CO on LPS-induced activation of endothelial cells (HUVEC). Methods: HUVEC were pretreated with CORM-2 at the concentration of 50 or 100μM for 2 hrs, washed and stimulated with LPS (10μg/ml) for ...

Aberrant c-erbB2 expression in cell clusters overlying focally disrupted breast myoepithelial cell layers: a trigger or sign for emergence of more aggressive cell clones?
Xichen Zhang, Shahreyar Shar Hashemi, Morvarid Yousefi, Jinsong Ni, Qiuyue Wang, Ling Gao, Pengtao Gong, Chunling Gao, Joy Sheng, Jeffrey Mason, Yan-gao Man More detail

Our recent studies revealed that cell clusters overlying focal myoepithelial cell layer disruption (FMCLD) had a significantly higher frequency of genetic instabilities and expression of invasion-related genes than their adjacent counterparts within the same duct. Our current study attempted to assess whether these cell clusters would also have ...

Bad seeds produce bad crops: a single stage-process of prostate tumor invasion
Yan-gao Man, William A. Gardner More detail

It is a commonly held belief that prostate carcinogenesis is a multi-stage process and that tumor invasion is triggered by the overproduction of proteolytic enzymes. This belief is consistent with data from cell cultures and animal models, whereas is hard to interpret several critical facts, including the presence of cancer in ...

In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”
Bradley Hyman More detail


PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice
Walter E. Rodriguez, Utpal Sen, Neetu Tyagi, Munish Kumar, Gene Carneal, Deep Aggrawal, Justin Newsome, Suresh C. Tyagi More detail

Authors are encouraged to suggest names of reviewers. Accepted papers are published immediately. Submissions of previous review reports by other journals are welcome.
Biolsci.org
Background: Homocysteine (Hcy) is an independent cardiovascular risk factor; however, in diabetes, the role of tissue Hcy leading to cardiac dysfunction is unclear. Aims: To determine whether tissue Hcy caused endothelial-myocyte uncoupling and ventricular dysfunction in diabetes. Methods: Diabetes was created in C57BL/6J male mice by injecting 65 ...

Dysregulated Mitochondrial Genes and Networks with Drug Targets in Postmortem Brain of Patients with Posttraumatic Stress Disorder (PTSD) Revealed by Human Mitochondria-Focused cDNA Microarrays
Yan A. Su, Jun Wu, Lei Zhang, Qiuyang Zhang, David M. Su, Ping He, Bi-Dar Wang, He Li, Maree J. Webster, Traumatic Stress Brain Study Group, Owen M. Rennert, Robert J. Ursano More detail

Posttraumatic stress disorder (PTSD) is associated with decreased activity in the dorsolateral prefrontal cortex (DLPFC), the brain region that regulates working memory and preparation and selection of fear responses. We investigated gene expression profiles in DLPFC Brodmann area (BA) 46 of postmortem patients with (n=6) and without PTSD (n=6) ...

Qualification and application of an ELISA for the determination of Tamm Horsfall Protein (THP) in human urine and its use for screening of Kidney Stone Disease
Wai-Hoe Lau, Wing-Seng Leong, Zhari Ismail, Lay-Harn Gam More detail

Kidney stone disease affects 1 - 20% of the general population. At present, the diagnosis of a stone is done using radiography method when noticeable symptoms appeared. We developed a non-invasive quantitative assay for urinary THP, namely ELISA; whereby our previous study and other reports had shown the usefulness of THP as biomarker for kidney ...

Relatively high levels of serum adiponectin in obese women, a potential indicator of anti-inflammatory dysfunction: Relation to sex hormone-binding globulin
Altan Onat, Gülay Hergenç, Dursun Dursunoğlu, Zekeriya Küçükdurmaz, Serkan Bulur, Günay Can More detail

It is unclear whether serum adiponectin concentrations diminish linearly with increasing adiposity and, if not, which factors codetermine this association. These issues were investigated cross-sectionally in 1188 men and women, representative of middle-aged and elderly Turkish adults. Serum total adiponectin was assayed by ELISA. Serum adiponectin ...

Generation and Validation of a Mouse Line with a Floxed SRC-3/AIB1 Allele for Conditional Knockout
Zhaoliang Liu, Lan Liao, Suoling Zhou, Jianming Xu More detail

The steroid receptor coactivator-3 (SRC-3), also known as AIB1, ACTR, p/CIP and NCOA3, is a transcriptional coactivator for nuclear receptors and certain other transcription factors. SRC-3 is widely expressed and plays important physiological functions and pathogenic roles in breast and prostate cancers. SRC-3 knockout (SRC-3-/-) mice display ...

New amyloid plaques or a game of hide-and-seek?
Kun Zou, Tomoji Maeda, Makoto Michikawa, Hiroto Komano More detail


STAT3 Activation in Pressure-Overloaded Feline Myocardium: Role for Integrins and the Tyrosine Kinase BMX
Christopher D. Willey, Arun P. Palanisamy, Rebecca K. Johnston, Santhosh K. Mani, Hirokazu Shiraishi, William J. Tuxworth, Michael R. Zile, Sundaravadivel Balasubramanian, Dhandapani Kuppuswamy More detail

Growth, survival and cytoskeletal rearrangement of cardiomyocytes are critical for cardiac hypertrophy. Signal transducer and activator of transcription-3 (STAT3) activation is an important cardioprotective factor associated with cardiac hypertrophy. Although STAT3 activation has been reported via signaling through Janus Kinase 2 (JAK2) in several ...

CO-releasing molecules (CORM-2)-liberated CO attenuates leukocytes infiltration in the renal tissue of thermally injured mice
Bingwei Sun, Zhiwei Sun, Qin Jin, Xi Chen More detail

Objective: To determine whether the CO-releasing molecule -liberated CO attenuates infiltration of leukocytes in the renal tissue of thermally injured mice. Materials and methods: Twenty-eight mice were assigned to four groups. Mice in sham group (n=7) were underwent sham thermal injury, whereas mice in burn group (n=7) received 15% total body ...

Differences in Trabecular Bone of Leptin-Deficient ob/ob Mice in Response to Biomechanical Loading
Hansjoerg Heep, Christian Wedemeyer, Alexander Wegner, Sebastian Hofmeister, Marius von Knoch More detail

Objective: It is known that bone mineral density (BMD) and the strength of bone is predicted by body mass. Fat mass is a significant predictor of bone mineral density which correlates with body weight. This suggests that body fat regulates bone metabolism first by means of hormonal factors and second that the effects of muscle and loading are ...

The Role of Erythropoietin as an Inhibitor of Tissue Ischemia
Nikolaos Paschos, Marios G. Lykissas, Alexandros E. Beris More detail

Erythropoietin is a hypoxia-induced cytokine that stimulates erythropoiesis through the promotion of erythroid precursor cell proliferation and differentiation. Recent evidence supports that erythropoietin has a broad spectrum of tissue protecting actions affecting other systems than hemopoietic. Lately, research has focused on the nonhemopoietic ...

Evaluation of the effects of a new drug candidate (GEMSP) in a chronic EAE model
A. Mangas, R. Coveñas, D. Bodet, M. de León, S. Duleu, M. Geffard More detail

Chronic Experimental Autoimmune Encephalomyelitis (EAE) was induced in rats to evaluate a new drug candidate (GEMSP) for the treatment of multiple sclerosis. This work is a part of preclinical studies on GEMSP, which is made up of fatty acids, vitamins and amino acids or their derivatives; all these compounds were linked to Poly-L-Lysine. In order ...

Genetic Linkage Map of Olive Flounder, Paralichthys olivaceus
Jung-Ha Kang, Woo-Jin Kim, Woo-Jai Lee More detail

No more wait for lengthy publication time in other journals only to find that other researchers/labs have published the same results. Submit your manuscripts today.
Biolsci.org
Olive flounder, Paralichthys olivaceus, is an important fish species in Asia, both for fisheries and aquaculture. As the first step for better understanding the genomic structure and functional analysis, we constructed a genetic linkage map for olive flounder based on 180 microsatellites and 31 expressed sequence tag (EST)-derived markers. ...

Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells
Athanassios Vassilopoulos, Rui-Hong Wang, Constantinos Petrovas, David Ambrozak, Richard Koup, Chu-Xia Deng More detail

It is hypothesized that cancer stem cells arise either from normal stem cells or from progenitor cells that have gained the ability to self-renew. Here we determine whether mammary cancer stem cells can be isolated by using antibodies that have been used for the isolation of normal mammary stem cells. We show that BRCA1 mutant cancer cell lines ...

Sex Hormones' Regulation of Rodent Physical Activity: A Review
J. Timothy Lightfoot More detail

There is a large body of emerging literature suggesting that physical activity is regulated to a varying extent by biological factors. Available animal data strongly suggests that there is a differential regulation of physical activity by sex and that the majority of this differential regulation is mediated by estrogen/testosterone pathways with ...

Relationship between calcium decoding elements and plant abiotic-stress resistance
Wei-Yi Song, Zheng-Bin Zhang, Hong-Bo Shao, Xiu-Lin Guo, Hong-Xing Cao, Hong-Bin Zhao, Zheng-Yan Fu, Xiao-Jun Hu More detail

Serving as an important second messenger, calcium ion has unique properties and universal ability to transmit diverse signals that trigger primary physiological actions in cells in response to hormones, pathogens, light, gravity, and stress factors. Being a second messenger of paramount significance, calcium is required at almost all stages of ...

Association between the frequency of class II HLA antigens and the susceptibility to intrauterine infection of hepatitis B virus
Yuan-yong Xu, Ji-yun Yu, Yan-wei Zhong, Hong-bin Song, Hui-hui Liu, Lei-li Jia, Shen-long Li, Jian-qiu Xu, Qiao Li More detail

Multiple factors determine the susceptibility to intrauterine hepatitis B virus (HBV) infection. These factors include the HBV structure, HBV mutation, HBV DNA level, placental barrier, the immune status of the mother, and the genetic make-ups of the newborn infants. Since HLA system is an integral component of the immune response, we hypothesized ...

Screening of Human Antibody Fab Fragment against HBsAg and the Construction of its dsFv Form
Leili Jia, Jiyun Yu, Hongbin Song, Xuelin Liu, Weina Ma, Yuanyong Xu, Chuanfu Zhang, Shicun Dong, Qiao Li More detail

The objective of this study was to pursue the techniques involving the screening of the human antibody Fab fragment against hepatitis B virus surface antigen (HBsAg) and the construction of its disulfide-stabilized Fv fragment (dsFv). The phage antibody Fab fragments against HBsAg were screened from the human combinatorial immunoglobulin library. ...

Comparative understanding of UTS2 and UTS2R genes for their involvement in type 2 diabetes mellitus
Zhihua Jiang, Jennifer J. Michal, David J. Tobey, Zeping Wang, Michael D. MacNeil, Nancy S. Magnuson More detail

Several reports have shown that urotensin 2 (UTS2) and its receptor (UTS2R) are involved in glucose metabolism and insulin resistance, which lead to development of type 2 diabetes mellitus (T2DM) in humans. In the present study, we annotated both bovine UTS2 and UTS2R genes and identified 5 single nucleotide polymorphisms (SNPs) for the former ...

Mutation at Tyrosine in AMLRY (GILRY Like) Motif of Yeast eRF1 on Nonsense Codons Suppression and Binding Affinity to eRF3
Akhmaloka, Prima Endang Susilowati, Subandi, Fida Madayanti More detail

Termination translation in Saccharomyces cerevisiae is controlled by two interacting polypeptide chain release factors, eRF1 and eRF3. Two regions in human eRF1, position at 281-305 and position at 411-415, were proposed to be involved on the interaction to eRF3. In this study we have constructed and characterized yeast eRF1 mutant at position 410 ...

Interactions between SNP Alleles at Multiple Loci Contribute to Skin Color Differences between Caucasoid and Mongoloid Subjects
Sumiko Anno, Takashi Abe, Takushi Yamamoto More detail

This study aimed to identify single nucleotide polymorphism (SNP) alleles at multiple loci associated with racial differences in skin color using SNP genotyping. A total of 122 Caucasians in Toledo, Ohio and 100 Mongoloids in Japan were genotyped for 20 SNPs in 7 candidate genes, encoding the Agouti signaling protein (ASIP), tyrosinase-related ...

Shedding Light on the Role of Vitreoscilla Hemoglobin on Cellular Catabolic Regulation by Proteomic Analysis
Chartchalerm Isarankura-Na-Ayudhya, Patcharee Panpumthong, Teerawit Tangkosakul, Somchai Boonpangrak, Virapong Prachayasittikul More detail

Heterologous expression of Vitreoscilla hemoglobin (VHb) has been reported to improve cell growth, protein synthesis, metabolite productivity and nitric oxide detoxification. Although it has been proposed that such phenomenon is attributed to the enhancement of respiration and energy metabolism by facilitating oxygen delivery, the mechanism of VHb ...

Effect of UVA Fluence Rate on Indicators of Oxidative Stress in Human Dermal Fibroblasts
James D. Hoerter, Christopher S. Ward, Kyle D. Bale, Admasu N. Gizachew, Rachelle Graham, Jaclyn Reynolds, Melanie E. Ward, Chesca Choi, Jean-Leonard Kagabo, Michael Sauer, Tara Kuipers, Timothy Hotchkiss, Nate Banner, Renee A. Chellson, Theresa Ohaeri, Langston Gant, Leah Vanderhill More detail

During the course of a day human skin is exposed to solar UV radiation that fluctuates in fluence rate within the UVA (290-315 nm) and UVB (315-400 nm) spectrum. Variables affecting the fluence rate reaching skin cells include differences in UVA and UVB penetrating ability, presence or absence of sunscreens, atmospheric conditions, and season and ...

Bioavailability of Heme Iron in Biscuit Filling Using Piglets as an Animal Model for Humans
Adrián Guillermo Quintero-Gutiérrez, Guillermina González-Rosendo, Jonathan Sánchez-Muñoz, Javier Polo-Pozo, José Juan Rodríguez-Jerez More detail

Full text in PubMed Central ensures that your article will be properly rendered and permanently available for readers of many generations to come.
Biolsci.org
The objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling. It comprised two stages: first, the development of the heme iron enriched biscuit filling; second, the evaluation of the bioavailability of the mineral in fattening piglets. Two groups were selected randomly and fed: a) Low iron feed and biscuits ...

ParaHox genes in pancreatic cell cultures: effects on the insulin promoter regulation
Anna Rosanas-Urgell, Jordi Garcia-Fernàndez, Gemma Marfany More detail

The gene encoding PDX1 (pancreatic duodenum homeobox 1), the main transcription factor regulating the glucose-dependent transactivation of the insulin promoter in pancreatic β-cells, clusters with two closely related homeobox genes (Gsh1 and Cdx2/3), all of them belonging to the ParaHox gene family. The ParaHox gene evolutionary history in ...

Activation of the FGF signaling pathway and subsequent induction of mesenchymal stem cell differentiation by inorganic polyphosphate
Yumi Kawazoe, Shinichi Katoh, Yuichiro Onodera, Takao Kohgo, Masanobu Shindoh, Toshikazu Shiba More detail

Inorganic polyphosphate [poly(P)] is a biopolymer existing in almost all cells and tissues, although its biological functions in higher eukaryotes have not been completely elucidated. We previously demonstrated that poly(P) enhances the function of fibroblast growth factors (FGFs) by stabilizing them and strengthening the affinity between FGFs and ...

Reduced white fat mass in adult mice bearing a truncated Patched 1
Zili Li, Heng Zhang, Leslie A. Denhard, Lan-Hsin Liu, Huaxin Zhou, Zi-Jian Lan More detail

Hedgehog (Hh) signaling emerges as a potential pathway contributing to fat formation during postnatal development. In this report, we found that Patched 1 (Ptc1), a negative regulator of Hh signaling, was expressed in the epididymal fat pad of adult mice. Reduced total white fat mass and epididymal adipocyte cell size were observed in naturally ...

Neurophysiologic Measurement of Continuity in the Sleep of Fetuses during the Last Week of Pregnancy and in Newborns
Adrián Poblano, Reyes Haro, Carmina Arteaga More detail

Our aim was to measure the correlation between fetal electrocardiographic (FECG) recordings of low-risk pregnancies and polysomnographic (PSG) study parameters in low-risk infants born at term as a measurement of perinatal sleep-development continuity. We designed a short, prospective, observational follow-up of physiologic parameters between ...

Quantitative analysis on the characteristics of targets with FDA approved drugs
Meena K. Sakharkar, Peng Li, Zhaowei Zhong, Kishore R. Sakharkar More detail

Accumulated knowledge of genomic information, systems biology, and disease mechanisms provide an unprecedented opportunity to elucidate the genetic basis of diseases, and to discover new and novel therapeutic targets from the wealth of genomic data. With hundreds to a few thousand potential targets available in the human genome alone, target ...

Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells
Hong-Bo Shao, Li-Ye Chu, Zhao-Hua Lu, Cong-Min Kang More detail

Antioxidants in plant cells mainly include glutathione, ascorbate, tocopherol, proline, betaine and others, which are also information-rich redox buffers and important redox signaling components that interact with cellular compartments. As an unfortunate consequence of aerobic life for higher plants, reactive oxygen species (ROS) are formed by ...

Transplantation of adult neural progenitor cells transfected with Vascular Endothelial Growth Factor rescues grafted cells in the rat brain
Martin H. Maurer, Christine Thomas, Heinrich F. Bürgers, Wolfgang Kuschinsky More detail

Growth factors are currently evaluated as therapeutics in stroke and neurodegeneration. Besides direct neurotrophic effects, they promote proliferation, survival, and differentiation of both transplanted and endogenous neural precursor cells (NPCs). In the current study, we investigated whether NPCs expressing Vascular Endothelial Growth Factor ...
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